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Article

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis.

Current opinion in pharmacology - 1 Dec 2011

Tsai Li-Chun Lisa, Beavo Joseph A

Abstract excerpt

The second messenger, cAMP, is one of the most important regulatory signals for control of steroidogenesis. This review focuses on current knowledge about regulation of cyclic nucleotides by phosphodiesterases (PDEs) in steroidogenic tissues. The first PDE known to directly regulate steroidogenesis was PDE2, the cGMP-stimulated PDE. PDE2 mediates ANP/cGMP-induced decreases in aldosterone production. Recently, the...

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Identifiers

PMID: 21962440
DOI: 10.1016/j.coph.2011.09.003
PMCID: PMC4034742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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