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Article

PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis.

International journal of molecular sciences - 21 Apr 2020

Barbagallo Federica, Rotilio Valentina, Assenza Maria Rita, Aguanno Salvatore, Orsini Tiziana, Putti Sabrina, Isidori Andrea M, Lenzi Andrea, Naro Fabio, De Angelis Luciana, Pellegrini Manuela

Abstract excerpt

Phosphodiesterase 2A (PDE2A) is a cAMP-cGMP hydrolyzing enzyme essential for mouse development and the PDE2A knockout model (PDE2A-/-) is embryonic lethal. Notably, livers of PDE2A-/- embryos at embryonic day 14.5 (E14.5) have extremely reduced size. Morphological, cellular and molecular analyses revealed loss of integrity in the PDE2A-/- liver niche that compromises the hematopoietic function and maturation....

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Identifiers

PMID: 32326334
DOI: 10.3390/ijms21082902
PMCID: PMC7215450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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