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Article

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

29 Dec 2004

Abstract excerpt

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a major regulator of monocyte to macrophage differentiation. In both humans and mice, the main phenotype of decreased GM-CSF function is pulmonary proteinosis due to aberrant function of alveolar macrophages. Recently, this cytokine has been shown to up-regulate a cyclic nucleotide phosphodiesterase, PDE1B. Two PDE1B variants with unique N-terminal...

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Identifiers

PMID: 15625104
DOI: 10.1073/pnas.0408535102

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