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Article

DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype.

International immunopharmacology - 1 Nov 2002

Jacob C, Leport M, Szilagyi C, Allen J M, Bertrand C, Lagente V

Abstract excerpt

The human promyelocytic HL60 cells acquired a neutrophilic phenotype after a 7- to 10-day DMSO treatment. Fc gammaRII was up-regulated. Fc gammaRI was also up-regulated by an additional IFN-gamma treatment. These cells are able to produce O2*- by NADPH oxidase activation in the presence of immune complexes or phorbol-12-myristate-13-acetate (PMA). A change of their PDE4 subtype profile was also observed: PDE4B...

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Identifiers

PMID: 12469939
DOI: 10.1016/s1567-5769(02)00141-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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