Article
Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells.
The Journal of biological chemistry - 18 Aug 2006
Szatmari Istvan, Vámosi György, Brazda Peter, Balint Balint L, Benko Szilvia, Széles Lajos, Jeney Viktoria, Ozvegy-Laczka Csilla, Szántó Attila, Barta Endre, Balla József, Sarkadi Balazs, Nagy Laszlo
Abstract excerpt
ABCG2, a member of the ATP-binding cassette transporters has been identified as a protective pump against endogenous and exogenous toxic agents. ABCG2 was shown to be expressed at high levels in stem cells and variably regulated during cell differentiation. Here we demonstrate that functional ABCG2 is expressed in human monocyte-derived dendritic cells by the activation of a nuclear hormone receptor, PPARgamma....
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