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Article

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Hahn Martin, Stachelhaus Torsten

Abstract excerpt

The interaction between enzymes of a nonribosomal peptide synthetase (NRPS) complex relies on the interplay of compatible sets of donor and acceptor communication-mediating (COM) domains. Hence, these domains are essential for the formation of a defined biosynthetic template, thereby directing the synthesis of a specific peptide product. Without the selectivity provided by different sets of COM domains, NRPSs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16407157
DOI: 10.1073/pnas.0508409103
PMCID: PMC1326170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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