Article
Common sequence on distinct V beta genes defines a protective idiotope in experimental encephalomyelitis.
Journal of neuroscience research - 1 Mar 1992
Vainiene M, Gold D P, Celnik B, Hashim G A, Vandenbark A A, Offner H
Abstract excerpt
Synthetic TCR peptides expressed by encephalitogenic T cells can induce both cellular and humoral responses that protect against experimental encephalomyelitis. In the Lewis rat, encephalitogenic T cells predominantly express V beta 8.2, and a peptide in the CDR2 region representing residues 39-5...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CD4 Antigens
- CD8 Antigens
- DNA
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Gene Amplification
- Hypersensitivity, Delayed
- Immunoglobulin Idiotypes
- Molecular Sequence Data
- Phenotype
- Rats
- Rats, Inbred Strains
- T-Lymphocytes