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Article

Common sequence on distinct V beta genes defines a protective idiotope in experimental encephalomyelitis.

Journal of neuroscience research - 1 Mar 1992

Vainiene M, Gold D P, Celnik B, Hashim G A, Vandenbark A A, Offner H

Abstract excerpt

Synthetic TCR peptides expressed by encephalitogenic T cells can induce both cellular and humoral responses that protect against experimental encephalomyelitis. In the Lewis rat, encephalitogenic T cells predominantly express V beta 8.2, and a peptide in the CDR2 region representing residues 39-59 could both protect against and treat experimental autoimmune encephalitis (EAE). Similarly, the homologous and cross...

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Source

Identifiers

PMID: 1640493
DOI: 10.1002/jnr.490310303

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common sequence on distinct V beta genes defines a protective idiotope in experimental encephalomyelitis.PMID 1640493Read ↗

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Effect of DAB(389)IL-2 immunotoxin on the course of experimental autoimmune encephalomyelitis in Lewis rats.Semantic proximity Read ↗

T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.Semantic proximity Read ↗

Differential CD4/CD8 subset-specific expression of highly homologous rat Tcrb-V8 family members suggests a role of CDR2 and/or CDR4 (HV4) in MHC class-specific thymic selection.Semantic proximity Read ↗

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