Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.

doi:10.1016/S0022-4804(03)00335-4

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Article

Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.

The Journal of surgical research - 1 Apr 2004

Mithani Suhail K, Balch Glen C, Shiou Sheng-Ru, Whitehead Robert H, Datta Pran K, Beauchamp R Daniel

Abstract excerpt

BACKGROUND: Smad proteins play a key role in TGF-beta signaling that regulates cell proliferation, differentiation, and apoptosis. Mice deficient in Smad3 develop colonic adenocarcinoma. MATERIALS AND METHODS: We developed a Smad3-deficient colonocyte cell line that was used to study TGF-beta-mediated growth inhibition and induction of apoptosis was compared to young adult mouse colonocyte (YAMC) control cells....

Topics

Animals
Apoptosis
Cell Division
Cell Line
Colon
DNA-Binding Proteins
Growth Inhibitors
Intestinal Mucosa
Mice
Mice, Transgenic
Mutation
Promoter Regions, Genetic
Smad3 Protein
Trans-Activators
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 15047135
DOI: 10.1016/S0022-4804(03)00335-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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