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Article

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.

PloS one - 1 Jan 2015

Thys An, Vandenberghe Pierre, Hague Perrine, Klein Ophir D, Erneux Christophe, Vanderwinden Jean-Marie

Abstract excerpt

Gastrointestinal stromal tumors, which are thought to derive from interstitial cells of Cajal or their precursors, often harbor an oncogenic mutation of the KIT receptor tyrosine kinase. Sprouty homolog 4, a known negative regulator of ERK pathway, has been identified in the interstitial cells of Cajal in the KitK641E murine model of gastrointestinal stromal tumors. Sprouty homolog 4 was upregulated both at the...

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Identifiers

PMID: 25923139
DOI: 10.1371/journal.pone.0124861
PMCID: PMC4414615

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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