Article
Allele and haplotype frequency at human leucocyte antigen class I/II and immunomodulatory cytokine loci in patients with myelodysplasia and acute myeloid leukaemia: in search of an autoimmune aetiology.
British journal of haematology - 1 Jun 2002
Gowans Duncan, O'Sullivan Alan, Rollinson Sara, Roddam Phillipa, Groves Mike, Fegan Chris, Morgan Gareth, Bowen David
Abstract excerpt
An autoimmune mechanism in the pathogenesis of myelodysplastic syndrome (MDS) is suggested by response to immunosuppression, with CD8+ T-lymphocytes implicated in the haematopoietic suppression. We therefore sought evidence for human leucocyte antigen (HLA) restriction and variant frequency differences in selected polymorphisms at the loci for the immunomodulatory cytokines, tumour necrosis factor alpha...
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