Article
Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells.
International immunopharmacology - 1 Feb 2006
Lee Jie-Jen, Liao Hui-Fen, Yang Yuh-Cheng, Liu Chien-Liang, Chen Yu-Yawn, Lin Chin-Ping, Chen Yu-Jen
Abstract excerpt
Platonin is a photosensitizer with NF-kappaB inhibitory activity that activates macrophages and suppresses lymphocyte response. In this study, we tested the effect of platonin on differentiation and maturation of human myeloid dendritic cells (DC) from CD14+ monocytes. Triggering of DC differentiation by GM-CSF and IL-4 resulted in typical immature DCs that were further stimulated to maturation by combination of...
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