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Article

Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotype.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 15 Feb 2015

Hardardottir Ingibjorg, Olafsdottir Elin Soffia, Freysdottir Jona

Abstract excerpt

Annotine is a lycopodane-type alkaloid isolated from the Icelandic club moss Lycopodium annotinum ssp. alpestre. Annotine does not inhibit acetylcholinesterase, as some other lycopodium alkaloids do, and other bioactivities have not been reported. The aim of this study was to determine the effects of annotine on maturation of dendritic cells (DCs) and their ability to activate allogeneic CD4(+) T cells. Human...

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Identifiers

PMID: 25765833
DOI: 10.1016/j.phymed.2014.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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