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Article

Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.

Cytokine - 1 Jan 2015

Leplina Olga Yu, Tyrinova Tamara V, Tikhonova Marina A, Ostanin Alexander A, Chernykh Elena R

Abstract excerpt

Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendritic cells (DCs) generated in the presence of IL-4/GM-CSF (IL4-DCs) and IFNα/GM-CSF (IFN-DCs). We...

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Identifiers

PMID: 25174880
DOI: 10.1016/j.cyto.2014.07.258

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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