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Article

Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo.

Blood - 1 May 2006

Patrignani Paola, Di Febbo Concetta, Tacconelli Stefania, Moretta Valeria, Baccante Giovanna, Sciulli Maria G, Ricciotti Emanuela, Capone Marta L, Antonucci Ivana, Guglielmi Maria D, Stuppia Liborio, Porreca Ettore

Abstract excerpt

The recent demonstration that platelets express a functional toll-like receptor 4 (TLR4) prompted us to explore the influence of TLR4 polymorphisms (Asp299Gly alone or in combination with Thr399Ile) on thromboxane A(2) (TXA(2)) biosynthesis in vivo. In 17 subjects with TLR4 polymorphisms versus 1...

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Source

Identifiers

PMID: 16397127
DOI: 10.1182/blood-2005-12-4811

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16397127-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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