Article
Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.
British journal of haematology - 1 Oct 2005
Coppola Antonio, D'Angelo Armando, Fermo Isabella, Mazzola Giuseppina, Di Minno Matteo Nicola Dario, Cajani Alessia, Sala Angelo, Folco Giancarlo, Tremoli Elena, Di Minno Giovanni
Abstract excerpt
The protective role of folate in vascular disease has been related to antioxidant effects. In 45 patients with previous early-onset (at age <50 years) thrombotic episodes and the 677TT methylenetetrahydrofolate reductase genotype, we evaluated the effects of a 28 d-course (15 mg/d) of 5-methyltetrahydrofolate (MTHF) on homocysteine metabolism and on in vivo generation of 8-iso-prostaglandin F2alpha...
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