Article
p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis.
Human mutation - 1 Jan 2000
Soussi T, Dehouche K, Béroud C
Abstract excerpt
The p53 tumor suppressor gene has proven to be one of the genes most often mutated in human cancers. It involves mainly point mutations leading to amino acid substitutions in the central region of the protein which impairs normal functions. Analysis of the mutational events that target the p53 gene has revealed evidence for both exogenous and endogenous mutational mechanisms. For example, the p53 mutational...
Topics
- Carcinogens
- Cell Transformation, Neoplastic
- Database Management Systems
- Genes, p53
- Humans
- Internet
- Molecular Epidemiology
- Mutation
- Neoplasms
