Article
Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations.
Human mutation - 1 Jan 2005
Soussi Thierry, Kato Shunsuke, Levy Pierre P, Ishioka Chikashi
Abstract excerpt
TP53 alteration is the most frequent genetic alteration found in human cancers. To date, more than 15,000 tumors with TP53 mutations have been published, leading to the description of more than 1,500 different TP53 mutants (http://p53.curie.fr). The frequency of these mutants is highly heterogeneous, with 11 hotspot mutants found more than 100 times, whereas 306 mutants have been reported only once. So far,...
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