Article
Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis.
International journal of cancer - 15 Apr 2008
Guan Yanlei, Hata Nobuhiro, Kuga Daisuke, Yoshimoto Koji, Mizoguchi Masahiro, Shono Tadahisa, Suzuki Satoshi O, Tahira Tomoko, Kukita Yoji, Higasa Koichiro, Yokoyama Nobuhiko, Nagata Shinji, Iwaki Toru, Sasaki Tomio, Hayashi Kenshi
Abstract excerpt
Mapping loss of heterozygosity (LOH) regions in the genomes of tumor tissues is a practical approach for identifying genes whose loss is related to tumorigenesis. Conventional LOH analyses using microsatellite or single nucleotide polymorphism (SNP) markers require the simultaneous examination of tumor- and matched normal-DNA. Here, we improved the previously developed SNP-based LOH assay using single strand...
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