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Article

Effect of oriented or random PEGylation on bioactivity of a factor VIII inhibitor blocking peptide.

Biotechnology and bioengineering - 5 Mar 2006

Kopecky Eva-Maria, Greinstetter Sabine, Pabinger Ingrid, Buchacher Andrea, Römisch Jürgen, Jungbauer Alois

Abstract excerpt

Peptides as therapeutic substances are efficient agents in the treatment of several diseases. However, they often have to be chemically modified in order to be suited as therapeutic agent. Conjugation to large carrier molecules is often required. A critical step is the identification of available sites for chemical reaction, without influencing bioactivity. Peptide 238/S1 with the sequence NH(2)-PYWKWQYKYD-COOH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16395719
DOI: 10.1002/bit.20706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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