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Article

Mutational analysis of a blood coagulation factor VIII-binding peptide.

The journal of peptide research : official journal of the American Peptide Society - 1 Apr 2002

Pflegerl K, Hahn R, Berger E, Jungbauer A

Abstract excerpt

A peptide screened from a combinatorial peptide library with the sequence EYKSWEYC performed best as a ligand for affinity chromatography of human blood coagulation factor VIII (FVIII). With this peptide immobilized on monolithic CIM columns via epoxy groups we were able to capture FVIII from diluted plasma. Rational substitution of amino acids by spot synthesis revealed that lysine and cysteine can be exchanged...

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Identifiers

PMID: 11972751
DOI: 10.1034/j.1399-3011.2002.1o965.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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