Article
Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs.
Human mutation - 1 Feb 2006
Gaustadnes Mette, Ørntoft Torben F, Jensen Jens Ledet, Torring Niels
Abstract excerpt
Colorectal cancer (CRC) is a multifactorial disease that involves both lifestyle and genetic factors. To identify single nucleotide polymorphisms (SNPs) associated with sporadic CRC, we used pooled DNA samples representing 230 cases with sporadic CRC and 540 controls. The allele frequency of the SNPs was estimated in the two pools using a genotyping method based on primer extension and capillary electrophoresis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.