Article
Likelihood-based methods for regression analysis with binary exposure status assessed by pooling.
Statistics in medicine - 28 Sept 2012
Lyles Robert H, Tang Li, Lin Ji, Zhang Zhiwei, Mukherjee Bhramar
Abstract excerpt
The need for resource-intensive laboratory assays to assess exposures in many epidemiologic studies provides ample motivation to consider study designs that incorporate pooled samples. In this paper, we consider the case in which specimens are combined for the purpose of determining the presence or absence of a pool-wise exposure, in lieu of assessing the actual binary exposure status for each member of the pool....
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