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Article

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Pasqualucci Laura, Kitaura Yasuyuki, Gu Hua, Dalla-Favera Riccardo

Abstract excerpt

During humoral immune responses, two distinct genetic modification events diversify the Ig genes in germinal center (GC) B cells: somatic hypermutation and class switch recombination (CSR). Both processes require the activity of activation-induced cytidine deaminase (AID), an enzyme expressed specifically in GC B cells. However, the mechanisms that regulate AID activity are largely unknown. Here we report that...

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Identifiers

PMID: 16387847
DOI: 10.1073/pnas.0509969103
PMCID: PMC1326186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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