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Article

Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation.

Toxicology - 15 Feb 2006

Godderis Lode, Aka Peter, Mateuca Raluca, Kirsch-Volders Micheline, Lison Dominique, Veulemans Hendrik

Abstract excerpt

Styrene oxide (SO), ethylene oxide (EO) and gamma-radiation (G) are agents with a well-described metabolism and genotoxicity. EPHX1 and GSTs play an important role in the detoxification of electrophiles and oxidative stress. Enzymes involved in base excision repair (hOGG1, XRCC1), in rejoining single strand breaks (XRCC1) and in repair of cross-links and chromosomal double strand breaks (XRCC3) might have an...

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Source

Identifiers

PMID: 16386346
DOI: 10.1016/j.tox.2005.11.021

Genes

XRCC3
XRCC1
EPHX1
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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