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Article

Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.

Molecular and cellular biology - 1 Jan 2006

Duchniewicz Marlena, Zemojtel Tomasz, Kolanczyk Mateusz, Grossmann Steffen, Scheele Jürgen S, Zwartkruis Fried J T

Abstract excerpt

Studies in tissue culture cells have demonstrated a role for the Ras-like GTPase Rap1 in the regulation of integrin-mediated cell-matrix and cadherin-mediated cell-cell contacts. To analyze the function of Rap1 in vivo, we have disrupted the Rap1A gene by homologous recombination. Mice homozygous for the deletion allele are viable and fertile. However, primary hematopoietic cells isolated from spleen or thymus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16382154
DOI: 10.1128/MCB.26.2.643-653.2006
PMCID: PMC1346907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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