Article
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.
Molecular psychiatry - 1 Dec 2004
Macgregor S, Visscher P M, Knott S A, Thomson P, Porteous D J, Millar J K, Devon R S, Blackwood D, Muir W J
Abstract excerpt
In this study, we report a genome scan for psychiatric disease susceptibility loci in 13 Scottish families. We follow up one of the linkage peaks on chromosome 1q in a substantially larger sample of 22 families affected by schizophrenia (SCZ) or bipolar affective disorder (BPAD). To minimise the effect of genetic heterogeneity, we collected mainly large extended families (average family size >18). The families...
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