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Article

DAF-12 regulates a connected network of genes to ensure robust developmental decisions.

PLoS genetics - 1 Jul 2011

Hochbaum Daniel, Zhang Yue, Stuckenholz Carsten, Labhart Paul, Alexiadis Vassili, Martin René, Knölker Hans-Joachim, Fisher Alfred L

Abstract excerpt

The nuclear receptor DAF-12 has roles in normal development, the decision to pursue dauer development in unfavorable conditions, and the modulation of adult aging. Despite the biologic importance of DAF-12, target genes for this receptor are largely unknown. To identify DAF-12 targets, we performed chromatin immunoprecipitation followed by hybridization to whole-genome tiling arrays. We identified 1,175 genomic...

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Identifiers

PMID: 21814518
DOI: 10.1371/journal.pgen.1002179
PMCID: PMC3140985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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