Article

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

2022-11-30

Abstract excerpt

Fibrillin-1 assembles into microfibrils that not only define the structural integrity and biomechanics of the aorta but also target and sequester growth factors within the extracellular microenvironment of aortic resident cells. To better understand how dominant negative effects on fibrillin microfibril stability manifest in growth factor driven aortic disease, we analyzed early events of aortic aneurysm formation...

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Literature Corpus work: 580b5826-86c6-5a4b-9efe-781b1860a124
DOI: 10.1101/2022.11.30.518511

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