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Article

The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology.

International journal of molecular sciences - 8 Feb 2022

Asano Keiichi, Cantalupo Anna, Sedes Lauriane, Ramirez Francesco

Abstract excerpt

Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key physical and mechanical properties to virtually every tissue, alone and together with elastin in the elastic fibers. Mutations in fibrillin-1 cause pleiotropic manifestations in Marfan syndrome (MFS), including dissecting thoracic aortic aneurysms, myocardial dysfunction, progressive bone loss, disproportionate...

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Identifiers

PMID: 35163812
DOI: 10.3390/ijms23031892
PMCID: PMC8836826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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