Article
Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment.
Genesis (New York, N.Y. : 2000) - 1 Aug 2012
Cook Jason R, Smaldone Silvia, Cozzolino Carmine, del Solar Maria, Lee-Arteaga Sui, Nistala Harikiran, Ramirez Francesco
Abstract excerpt
Loss-of-function experiments in mice have yielded invaluable mechanistic insights into the pathogenesis of Marfan syndrome (MFS) and implicitly, into the multiple roles fibrillin-1 microfibrils play in the developing and adult organism. Unfortunately, neonatal death from aortic complications of mice lacking fibrillin-1 (Fbn1(-/-) mice) has limited the scope of these studies. Here, we report the creation of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.