GERBIL: Genotype resolution and block identification using likelihood.

doi:10.1073/pnas.0404730102

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Article

GERBIL: Genotype resolution and block identification using likelihood.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005

Kimmel Gad, Shamir Ron

Abstract excerpt

The abundance of genotype data generated by individual and international efforts carries the promise of revolutionizing disease studies and the association of phenotypes with individual polymorphisms. A key challenge is providing an accurate resolution (phasing) of the genotypes into haplotypes. We present here results on a method for genotype phasing in the presence of recombination. Our analysis is based on a...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 5
Computer Simulation
Data Interpretation, Statistical
Female
Humans
Likelihood Functions
Male
Models, Genetic
Polymorphism, Single Nucleotide
Software

Source

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Identifiers

PMID: 15615859
DOI: 10.1073/pnas.0404730102
PMCID: PMC544046

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