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Article

Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance.

Journal of hepatology - 1 Sept 2000

Gutfreund K S, Williams M, George R, Bain V G, Ma M M, Yoshida E M, Villeneuve J P, Fischer K P, Tyrrel D L

Abstract excerpt

BACKGROUND/AIMS: Hepatitis B mutant strains of virus emerging during treatment with the nucleoside analog lamivudine are being increasingly recognized. In the majority of lamivudine-resistant isolates the mutations have been reported to occur within the YMDD motif of the viral polymerase, either...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11020004
DOI: 10.1016/s0168-8278(00)80284-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11020004-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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