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Article

Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.

Antimicrobial agents and chemotherapy - 1 Jul 2005

Pai S Balakrishna, Bozdayi A Mithat, Pai Rekha B, Beker Tolunay, Sarioglu Mustafa, Turkyilmaz Ahmet R, Grier Jason, Yurdaydin Cihan, Schinazi Raymond F

Abstract excerpt

The emergence of resistance to lamivudine has been one of the major stumbling blocks to successful treatment and control of hepatitis B virus (HBV) infections. The major mechanism of resistance has been attributed to the alteration in the YMDD motif of the HBV polymerase due to an amino acid chan...

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Share to DNA-Directed DNA Polymerase
Share to DNA, Viral
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

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Share to Mutagenesis, Site-Directed

Share to Reverse Transcriptase Inhibitors

Source

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Identifiers

PMID: 15980328
DOI: 10.1128/AAC.49.7.2618-2624.2005
PMCID: PMC1168680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15980328-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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