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Article

The structure of a thermostable mutant of pro-papain reveals its activation mechanism.

Acta crystallographica. Section D, Biological crystallography - 1 Dec 2012

Roy Sumana, Choudhury Debi, Aich Pulakesh, Dattagupta Jiban K, Biswas Sampa

Abstract excerpt

Papain is the archetype of a broad class of cysteine proteases (clan C1A) that contain a pro-peptide in the zymogen form which is required for correct folding and spatio-temporal regulation of proteolytic activity in the initial stages after expression. This study reports the X-ray structure of the zymogen of a thermostable mutant of papain at 2.6 Å resolution. The overall structure, in particular that of the...

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Identifiers

PMID: 23151624
DOI: 10.1107/S0907444912038607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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