Article

Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons

2024-12-28

Abstract excerpt

T-type/Cav3 calcium channels are key in neuronal excitability and pain processing with Cav3.2 being the prominent isoform in primary sensory neurons of the dorsal root ganglion (DRG). Its pharmacological inhibition or gene silencing induces analgesia in several preclinical models of inflammatory and neuropathic pain. However, the presence of Cav3.2, encoded by the CACNA1H gene, in human DRG neurons remains unreso...

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Literature Corpus work: 1e53e896-4b67-5e17-b0fa-b33619858990
DOI: 10.1101/2024.12.27.630548

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Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG NeuronsDOI 10.1101/2024.12.27.630548Read

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