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Article

Ins and outs of T-channel structure function.

Pflugers Archiv : European journal of physiology - 1 Apr 2014

Perez-Reyes Edward, Lee Jung-Ha

Abstract excerpt

We review the ins and outs of T-channel structure, focusing on the extracellular high-affinity metal-binding site and intracellular loops. The high-affinity metal-binding site was localized to repeat I of Cav3.2. Interestingly, a similar binding site was found in the high voltage-activated Cav2.3 channel where it controls the channels' voltage dependence. Histidine at position 191 has a particularly interesting...

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PMID: 24337909
DOI: 10.1007/s00424-013-1419-5

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