Article
A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye.
Cell - 29 Dec 2005
Li Xin, Carthew Richard W
Abstract excerpt
A critical question about signal transduction is how weak or transient activation of signaling pathways achieves a robust and long-term switch in gene expression. We report that a microRNA is part of a mechanism that makes cells sensitive to signals in the Drosophila eye. Expression of miR-7 is activated in cells as they begin differentiating into photoreceptors. This is dependent on EGF receptor (EGFR) signaling...
Topics
- Animals
- Cell Differentiation
- Conserved Sequence
- Drosophila
- Drosophila Proteins
- ErbB Receptors
- Eye
- Eye Proteins
- Genome
- MicroRNAs
- Models, Biological
- Mutation