Article
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.
Development (Cambridge, England) - 1 Oct 1998
Kumar J P, Tio M, Hsiung F, Akopyan S, Gabay L, Seger R, Shilo B Z, Moses K
Abstract excerpt
A new conditional Egfr allele was used to dissect the roles of the receptor in eye development and to test two published models. EGFR function is necessary for morphogenetic furrow initiation, is not required for establishment of the founder R8 cell in each ommatidium, but is necessary to maintai...
Topics
- Alleles
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Nucleus
- Cytoplasm
- Drosophila
- Drosophila Proteins
- Enzyme Activation
- ErbB Receptors
- Eye
- Eye Proteins
- Genes, Insect
- Membrane Glycoproteins
- Microscopy, Confocal
- Models, Biological
- Mutation
- Receptor Protein-Tyrosine Kinases
- Retina