Article
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.
Cell - 21 Aug 1992
Lai Z C, Rubin G M
Abstract excerpt
Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Eye Proteins
- Gene Expression Regulation
- Molecular Sequence Data
- Morphogenesis
- Mutation