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Article

Nuclear hormone receptor regulation of microRNAs controls developmental progression.

Science (New York, N.Y.) - 3 Apr 2009

Bethke Axel, Fielenbach Nicole, Wang Zhu, Mangelsdorf David J, Antebi Adam

Abstract excerpt

In response to small-molecule signals such as retinoids or steroids, nuclear receptors activate gene expression to regulate development in different tissues. MicroRNAs turn off target gene expression within cells by binding complementary regions in messenger RNA transcripts, and they have been broadly implicated in development and disease. Here we show that the Caenorhabditis elegans nuclear receptor DAF-12 and...

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Identifiers

PMID: 19342589
DOI: 10.1126/science.1164899
PMCID: PMC2757405

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