Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

doi:10.1016/0092-8674(95)90006-3

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Article

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

Cell - 16 Jun 1995

Rebay I, Rubin G M

Abstract excerpt

Drosophila yan has been postulated to act as an antagonist of the proneural signal mediated by the sevenless/Ras1/MAPK pathway. We have mutagenized the eight MAPK phosphorylation consensus sites of yan and examined the effects of overexpressing the mutant protein in transgenic flies and transfect...

Topics

Alleles
Animals
Binding Sites
Calcium-Calmodulin-Dependent Protein Kinases
DNA-Binding Proteins
Down-Regulation
Drosophila
Drosophila Proteins
Eye
Eye Proteins
GTP-Binding Proteins
Gene Expression Regulation, Developmental
Membrane Glycoproteins
Mutagenesis, Site-Directed
Neurons
Phosphorylation
Receptor Protein-Tyrosine Kinases
Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 7781063
DOI: 10.1016/0092-8674(95)90006-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7781063-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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