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Article

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

Cell - 16 Jun 1995

Rebay I, Rubin G M

Abstract excerpt

Drosophila yan has been postulated to act as an antagonist of the proneural signal mediated by the sevenless/Ras1/MAPK pathway. We have mutagenized the eight MAPK phosphorylation consensus sites of yan and examined the effects of overexpressing the mutant protein in transgenic flies and transfected S2 cultured cells. Our results suggest that phosphorylation by MAPK affects the stability and subcellular...

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PMID: 7781063
DOI: 10.1016/0092-8674(95)90006-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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