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Article

Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

Journal of viral hepatitis - 1 May 2000

Lohmann V, Roos A, Körner F, Koch J O, Bartenschlager R

Abstract excerpt

Hepatitis C virus (HCV), the major causative agent of chronic and sporadic non-A, non-B hepatitis worldwide, is a distinct member of the Flaviviridae virus family. These viruses have in common a plus-strand RNA genome that is replicated in the cytoplasm of the infected cell via minus-strand RNA intermediates. Owing to the lack of reliable cell culture systems and convenient animal models for HCV, the mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10849258
DOI: 10.1046/j.1365-2893.2000.00218.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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