Estimation of genetic and environmental factors for melanoma onset using population-based family data.

doi:10.1002/sim.2266

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Article

Estimation of genetic and environmental factors for melanoma onset using population-based family data.

Statistics in medicine - 30 Sept 2006

Lindström L, Pawitan Y, Reilly M, Hemminki K, Lichtenstein P, Czene K

Abstract excerpt

Estimation of genetic and environmental contributions to cancers falls in the framework of generalized linear mixed modelling with several random effect components. Computational challenges remain, however, in dealing with binary or survival phenotypes. In this paper, we consider the analysis of melanoma onset in a population of 2.6 million nuclear families in Sweden, for which none of the current survival-based...

Topics

Adolescent
Adult
Age of Onset
Aged
Child
Cocarcinogenesis
Environment
Family
Female
Genetic Predisposition to Disease
Humans
Male
Melanoma
Middle Aged
Models, Genetic
Models, Statistical
Pedigree
Sweden

Source

Open in PubMed

Identifiers

PMID: 16372390
DOI: 10.1002/sim.2266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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