Evaluation of bias in familial risk estimates: a study of common cancers using Swedish population-based registers.

Abstract excerpt

BACKGROUND: Bias in estimates of familial cancer may result if population-based registers fail to identify relatives as affected when disease occurs before the start-up of registration (ie, "left-truncation" of family history). METHODS: Apparent familial relative risks (among offspring of parents with cancer) of colorectal, lung, breast, and prostate cancers and melanoma in a Swedish cohort were compared with...

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