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Inheritable Histone H4 Acetylation of Somatic Chromatins in Cloned Embryos

22 Dec 2005

Abstract excerpt

A viable cloned animal indicates that epigenetic status of the differentiated cell nucleus is reprogrammed to an embryonic totipotent state. However, molecular events regarding epigenetic reprogramming of the somatic chromatin are poorly understood. Here we provide new insight that somatic chromatins are refractory to reprogramming of histone acetylation during early development. A low level of acetylated histone...

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PMID: 16371357
DOI: 10.1074/jbc.m511340200

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