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Aberrant epigenetic changes and gene expression in cloned cattle dying around birth

11 Feb 2008

Abstract excerpt

BACKGROUND: Aberrant reprogramming of donor somatic cell nuclei may result in many severe problems in animal cloning. To assess the extent of abnormal epigenetic modifications and gene expression in clones, we simultaneously examined DNA methylation, histone H4 acetylation and expression of six genes (beta-actin, VEGF, oct4, TERT, H19 and Igf2) and a repetitive sequence (art2) in five organs (heart, liver,...

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PMID: 18261243
DOI: 10.1186/1471-213x-8-14

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