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Transcriptional memory inherited from donor cells is a developmental defect of bovine cloned embryos

3 Dec 2019

Abstract excerpt

Studies on the effects of transcriptional memory on clone reprogramming in mammals are limited. In the present study, we observed higher levels of active histone H3 lysine 4 trimethylation (H3K4me3 and 5-hydroxymethylcytosine) and repressive (5-methylcytosine) epigenetic modifications in bovine early cloned embryos than in in vitro fertilized embryos. We hypothesized that aberrant epigenetic modification may...

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PMID: 31914649
DOI: 10.1096/fj.201900578rr

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