Article
Growth factor receptors: implications in tumor biology.
Current opinion in investigational drugs (London, England : 2000) - 1 Dec 2005
Srinivasan Divya Mani, Kapoor Mohit, Kojima Fumiaki, Crofford Leslie J
Abstract excerpt
Growth factors are signaling molecules which bind to cell surface receptors and mediate a myriad of intracellular functions. Growth factor signaling is vital for growth and differentiation of cells under normal physiological conditions. However, aberrant signaling of these molecules via their receptors enables the cells to acquire abnormal characteristics most commonly observed in tumor cells. Tumor biology...
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