Article
Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.
Human genetics - 1 Mar 2006
Bertoli-Avella Aida M, Dekker Marieke C J, Aulchenko Yurii S, Houwing-Duistermaat Jeanine J, Simons Erik, Testers Leon, Pardo Luba M, Rademaker Tessa A M, Snijders Pieter J L M, van Swieten John C, Bonifati Vincenzo, Heutink Peter, van Duijn Cornelia M, Oostra Ben A
Abstract excerpt
We studied patients with idiopathic Parkinson's disease (PD) from an isolated population in the Netherlands aiming to map gene(s) involved in PD susceptibility. A total of 109 parkinsonism patients were independently ascertained, of whom 62 presented late-onset, idiopathic PD. Genealogical research showed that 45 index cases with idiopathic PD were linked to a common ancestor, indicating familiar clustering among...
Topics
- Age of Onset
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 9
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- Genome, Human