Article
Fine-mapping and candidate gene investigation within the PARK10 locus.
European journal of human genetics : EJHG - 1 Mar 2009
Haugarvoll Kristoffer, Toft Mathias, Skipper Lisa, Heckman Michael G, Crook Julia E, Soto Alexandra, Ross Owen A, Hulihan Mary M, Kachergus Jennifer M, Sando Sigrid B, White Linda R, Lynch Timothy, Gibson J Mark, Uitti Ryan J, Wszolek Zbigniew K, Aasly Jan O, Farrer Matthew J
Abstract excerpt
Herein, we investigate whether single-nucleotide polymorphisms (SNPs) across the PARK10 locus are associated with susceptibility to Parkinson's disease (PD) or age at onset (AAO) of disease. One hundred and eighty-eight SNPs were genotyped across the PARK10 locus in 180 PD patients and 180 controls from central Norway (stage 1). We then used the linkage disequilibrium (LD) structure from stage 1 to select 75 SNPs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.